The Buddha most compassionately uttered that all humans suffer. All of us will get sick, have our hearts broken, experience the heartache of losing loved ones, and eventually die ourselves. This was the first Noble Truth.
But we also suffer because of our egos. Unlike death, sickness, and having our heart broken, we can control our egos. Ego is what drives us to do things that are out of accord with the way. Life can never appease the ego because it always wants more.